Drug utilization patterns and dosing appropriateness of antirheumatic drugs in outpatients with rheumatoid arthritis at Harapan dan Doa General Hospital, Bengkulu City, Indonesia

Silvia Juniarti; Reza Rahmawati; Evi Maryanti; Dian Handayani; Delia Komala Sari; Dwi Dominica Sari; Reza Pertiwi; Rizki Oktarini; Septi Wulandari

doi:10.51511/pr.106

Silvia Juniarti Department of Pharmacy, University of Bengkulu, Bengkulu, Indonesia
Reza Rahmawati Department of Pharmacy, University of Bengkulu, Bengkulu, Indonesia https://orcid.org/0000-0003-1891-1091
Evi Maryanti Department of Chemistry, University of Bengkulu, Bengkulu, Indonesia
Dian Handayani Department of Nursing, University of Borneo, Tarakan, North Kalimantan, Indonesia
Delia Komala Sari Department of Pharmacy, University of Bengkulu, Bengkulu, Indonesia
Dwi Dominica Sari Department of Pharmacy, University of Bengkulu, Bengkulu, Indonesia
Reza Pertiwi Department of Pharmacy, University of Bengkulu, Bengkulu, Indonesia
Rizki Oktarini Department of Pharmacy, University of Bengkulu, Bengkulu, Indonesia
Septi Wulandari Department of Pharmacy, University of Bengkulu, Bengkulu, Indonesia

Keywords: Disease-modifying antirheumatic drugs, drug utilization, nonsteroidal anti-inflammatory drugs, prescribing patterns, rheumatoid arthritis

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease that requires long-term treatment and careful management. Inappropriate therapy may increase morbidity and mortality; therefore, appropriate drug selection and prescribing are essential to improving healthcare quality, particularly in hospital settings. This study aimed to determine the prescribing patterns of medications for patients with rheumatoid arthritis at Harapan dan Doa General Hospital in Bengkulu City. A descriptive, quantitative design was employed, utilizing a total sampling technique. The results showed that, based on drug combination patterns, most patients received triple-drug therapy (46.66%), followed by dual therapy (31.61%) and monotherapy (21.64%). The most common monotherapy was etoricoxib (8.33%), while the most frequent two-drug combination was methotrexate and methylprednisolone (11.66%). The predominant three-drug combination consisted of methotrexate, methylprednisolone, and meloxicam (15%). Based on therapeutic class, the prescribed drugs included nonsteroidal anti-inflammatory drugs (NSAIDs) (80%), corticosteroids (71.66%), disease-modifying antirheumatic drugs (DMARDs) (61.66%), and analgesics (10%). Although all prescribed drugs followed the recommended dosing guidelines, NSAIDs and corticosteroids were used more frequently than methotrexate. This pattern may reflect variations in clinical practice or differences in patient characteristics.

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