The neuroprotective effects of Robusta coffee (Coffea canephora) on neurodegenerative diseases
Abstract
Neurodegenerative diseases represent a growing global health challenge, particularly in aging populations. This review examines the neuroprotective potential of Robusta coffee (Coffea canephora) and its bioactive compounds in neurodegenerative conditions. Robusta coffee contains a rich profile of bioactive compounds, including caffeine, chlorogenic acids, and other polyphenols, which demonstrate significant antioxidant, anti-inflammatory, and neuroprotective properties. Evidence from preclinical and epidemiological studies suggests that these compounds can modulate multiple pathways involved in neurodegenerative processes, including oxidative stress, neuroinflammation, and protein aggregation. This review synthesizes current findings on the molecular mechanisms underlying the neuroprotective effects of Robusta coffee components in conditions such as Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders. Recent advances in delivery systems, such as nanoparticle formulations, are also discussed as potential approaches to enhance the bioavailability and efficacy of coffee bioactives. By identifying the therapeutic potential of Robusta coffee components and highlighting gaps in current knowledge, this review provides a foundation for developing novel preventive and therapeutic interventions for neurodegenerative diseases based on these naturally occurring compounds.
References
Van Schependom J, D'haeseleer M. Advances in Neurodegenerative Diseases. J Clin Med. 2023;12(5):1-6. https://doi.org/10.3390/jcm12051709
Socała K, Szopa A, Serefko A, Poleszak E, Wlaź P. Neuroprotective effects of coffee bioactive compounds: A review. Int J Mol Sci. 2021;22(1):1-64. https://doi.org/10.3390/ijms22010107
Wahyudi MZ. Penyakit Neurodegeneratif, Ancaman di Depan Mata. Kompas.com. 2022. Available from: https://www.kompas.id/baca/humaniora/2023/02/21/penyakit-neurodegeneratif-ancaman-di-depan-mata
Halli-Tierney AD, Luker J, Carroll DG. Parkinson Disease. Am Fam Physician. 2020;102(11):679-691. https://doi.org/10.55606/jurrike.v2i2.1701
Bestari AP. Mengenal Demensia Alzheimer. Kementerian Kesehatan. 2023. Available from: https://yankes.kemkes.go.id/view_artikel/2819/mengenal-demensiaalzheimer
Wasim S, Kukkar V, Awad VM, Sakhamuru S, Malik BH. Neuroprotective and Neurodegenerative Aspects of Coffee and Its Active Ingredients in View of Scientific Literature. Cureus. 2020;12(8). https://doi.org/10.7759/cureus.9578
Permatasari N, Same M, Sari RPK, Fauziah LK. Analysis of Weed Vegetation in Robusta Coffee (Coffea robusta L.) Traditional Farm at Pesawaran, Lampung. Jurnal Biologi Tropis. 2023;23(4):67-75. https://doi.org/10.29303/jbt.v23i4.5422
Wijaya RY, Tamrin T, Sugianti C. Pengaruh Lama Fermentasi Menggunakan Mikroba Ghalkoff terhadap Perubahan Konsentrasi Kandungan Kafein Kopi Robusta Organik Kabupaten Lampung Barat. Jurnal Agricultural Biosystem Engineering. 2023;2(3):354. https://doi.org/10.23960/jabe.v2i3.7892
Widagdyo DR, Budiman VA, Aylianawati, Indraswati N. Ekstrasi Kafeina dari Serbuk Kopi Java Robusta dengan Pelarut Minyak Jagung. Widya Teknik. 2017;12(1):1-10.
Azzahra M, Abdurahman AI, Alamsyah A. Fenomena Ngopi di Coffee Shop Pada Gen Z. Social Science Academic. 2023;1(2):493-506. https://doi.org/10.37680/ssa.v1i2.3991
Herawati D, Risma Aulia Y, Fanny Rahmadani. Three major compounds showing significant antioxidative, α-glucosidase inhibition, and antiglycation activities in Robusta coffee brew. Int J Food Prop. 2019;22(1):994-1010. https://doi.org/10.1080/10942912.2019.1622562
Nguyen V, Taine EG, Meng D, Cui T, Tan W. Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials. Nutrients. 2024;16(7):924. https://doi.org/10.3390/nu16070924
Tandi J, Rosmala Dewi, Ayu Devita Sari GN, Jufri Bahar. Determination of Secondary Metabolites and Antioxidant Activity of Robusta Coffee Bean Ethanol Extract by UV - Vis Spectrophotometry. Jurnal Akademika Kimia. 2023;12(1):58-64. https://doi.org/10.22487/j24775185.2023.v12.i1.pp58-64
Walid MN. Skrining Senyawa Metabolit Sekunder Dan Total Fenol Kopi Robusta (Coffea canephora Pierre Ex a. Froehner) Di Daerah Petungkriyono Pekalongan. Pena Jurnal Ilmu Pengetahuan dan Teknologi. 2023;37(1):1-1. https://doi.org/10.31941/jurnalpena.v37i1.2928
Ihsan BRP, Amira Zahrani, Duha NA. Determination of caffeine in Robusta coffee beans with different roasting method using UV-Vis spectrophotometry. Food Research. 2023;7(6):29-34. https://doi.org/10.26656/fr.2017.7(6).1006
Suci PR, Angel V, Aini N. Perbandingan Variasi Lamanya Waktu Penyangraian Terhadap Kadar Kafein Pada Biji Kopi Robusta Secara Spektrofotometri UV-Vis. Jurnal Ilmu Kedokteran dan Kesehatan Indonesia. 2024;4(1):187-197. https://doi.org/10.55606/jikki.v4i1.2975
Yao J, Zhang B, Ge C, Peng S, Fang J. Xanthine oxidase inhibitory activity, antioxidant effects, and anti-inflammatory effects of chlorogenic acid. J Agric Food Chem. 2019;67(11):3198-3206. doi:10.1021/acs.jafc.9b00298
Naveed M, Hejazi V, Abbas M, Kamboh AA, Khan GJ, Shumzaid M, et al. Chlorogenic acid (CGA): A pharmacological review and call for further research. Biomed Pharmacother. 2018;97:67-74. https://doi.org/10.1016/j.biopha.2017.10.064
Ruggiero M, Calvello R, Porro C, Messina G, Cianciulli A, Panaro MA. Neurodegenerative Diseases: Can Caffeine Be a Powerful Ally to Weaken Neuroinflammation? Int J Mol Sci. 2022;23(21). https://doi.org/10.3390/ijms232112958
Mancini RS, Wang Y, Weaver DF. Phenylindanes in brewed coffee inhibit amyloid-beta and tau aggregation. Front Neurosci. 2018;12:735. https://doi.org/10.3389/fnins.2018.00735
Shah MA, Rai SN, Birla H, Zahra W, Rathore AS, Dilnashin H, et al. Chlorogenic acid attenuated brain cell death and memory impairment by enhancing neuroprotective effect of ferulic acid in MPTP intoxicated BALB/c mice. Int Immunopharmacol. 2021;96:107735. https://doi.org/10.1016/j.intimp.2021.107735
Zheng Y, Li L, Chen B, Fang Y, Lin W, Zhang T, et al. Chlorogenic acid exerts neuroprotective effect against hypoxia-ischemia brain injury in neonatal rats by activating Sirt1 to regulate the Nrf2-NF-κB signaling pathway. Cell Commun Signal. 2022;20(1):84. https://doi.org/10.1186/s12964-022-00860-0
Paiva C, Beserra B, Reis C, Dorea JG, Da Costa T, Amato AA. Consumption of coffee or caffeine and serum concentration of inflammatory markers: A systematic review. Crit Rev Food Sci Nutr. 2019;59(4):652-663. https://doi.org/10.1080/10408398.2017.1386159
Kolahdouzan M, Hamadeh MJ. The neuroprotective effects of caffeine in neurodegenerative diseases. CNS Neurosci Ther. 2017;23(4):272-290. https://doi.org/10.1111/cns.12684
Tajik N, Tajik M, Mack I, Enck P. The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature. Eur J Nutr. 2017;56(7):2215-2244. https://doi.org/10.1007/s00394-017-1379-1
Mikami Y, Yamazawa T. Chlorogenic acid, a polyphenol in coffee, protects neurons against glutamate neurotoxicity. Life Sci. 2015;139:69-74. https://doi.org/10.1016/j.lfs.2015.08.005
Amin FU, Shah SA, Kim MO. Vanillic acid attenuates Aβ1-42-induced oxidative stress and cognitive impairment in mice. Sci Rep. 2017;7(1):40753. https://doi.org/10.1038/srep40753
Jakova E, Aigbogun OP, Moutaoufik MT, Allen KJH, Munir O, Brown D, et al. The Bifunctional Dimer Caffeine-Indan Attenuates α-Synuclein Misfolding, Neurodegeneration and Behavioral Deficits after Chronic Stimulation of Adenosine A1 Receptors. Int J Mol Sci. 2024;25(17):9386. https://doi.org/10.3390/ijms25179386
Cornelis MC, Bennett DA, Weintraub S, Schneider JA, Morris MC. Caffeine consumption and dementia: Are Lewy bodies the link? Ann Neurol. 2022;91(6):834-846. https://doi.org/10.1002/ana.26349
Stazi M, Lehmann S, Sakib MS, Pena-Centeno T, Büschgens L, Fischer A, et al. Long-term caffeine treatment of Alzheimer mouse models ameliorates behavioural deficits and neuron loss and promotes cellular and molecular markers of neurogenesis. Cell Mol Life Sci. 2021;79(1):55. https://doi.org/10.1007/s00018-021-04062-8
Tira R, Viola G, Barracchia CG, Parolini F, Munari F, Capaldi S, et al. Espresso Coffee Mitigates the Aggregation and Condensation of Alzheimer's Associated Tau Protein. J Agric Food Chem. 2023;71(30):11429-11441. https://doi.org/10.1021/acs.jafc.3c01072
Takeshige-Amano H, Saiki S, Fujimaki M, Ueno SI, Li Y, Hatano T, et al. Shared Metabolic Profile of Caffeine in Parkinsonian Disorders. Mov Disord. 2020;35(8):1438-1447. https://doi.org/10.1002/mds.28068
Singh SS, Rai SN, Birla H, Zahra W, Rathore AS, Dilnashin H, et al. Neuroprotective Effect of Chlorogenic Acid on Mitochondrial Dysfunction-Mediated Apoptotic Death of DA Neurons in a Parkinsonian Mouse Model. Oxid Med Cell Longev. 2022;2022:6571484. doi:10.1155/2022/6571484
Medeiros MS, Schumacher-Schuh AF, Altmann V, Rieder CRM. A Case-Control Study of the Effects of Chimarrão (Ilex paraguariensis) and Coffee on Parkinson's Disease. Front Neurol. 2021;12:619535. https://doi.org/10.3389/fneur.2021.619535
Ruggiero M, Calvello R, Porro C, Messina G, Cianciulli A, Panaro MA. Neurodegenerative Diseases: Can Caffeine Be a Powerful Ally to Weaken Neuroinflammation? Int J Mol Sci. 2022;23(21). https://doi.org/10.3390/ijms232112958
Li X, Feng S, Wu Y, Li W, Yang S, Wang M, et al. Neuroprotective effects of chlorogenic acid in a mouse model of intracerebral hemorrhage associated with reduced extracellular matrix metalloproteinase inducer. Biomolecules. 2022;12(8):1020. https://doi.org/10.3390/biom12081020
Yunida Y, Kamaluddin MT, Theodorus T, Mangunsong S. Formulasi dan Karakterisasi Nanopartikel Kafein Hasil Isolasi dari Biji Kopi Robusta. Jurnal Mandala Pharmacon Indonesia. 2021;7(1):47-59. https://doi.org/10.35311/jmpi.v7i1.68
Mangunsong S, Kamaluddin MT, Theodorus T, Yunida Y. The Parameter Pharmacokinetics of Caffeine Nanoparticle Preparations from Robusta Coffee Extracted Using PLGA and PVA. Int J Res Sci Innov. 2022;09(12):94-98. https://doi.org/10.51244/IJRSI.2022.91207
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