Clinical efficacy of guava (Psidium guajava L.) in human trials: A review of therapeutic and nutritional applications
Abstract
This review examines clinical evidence for guava's therapeutic efficacy across multiple health domains. Randomized controlled trials reveal guava's significant impacts on metabolic health, demonstrating reduced postprandial glucose responses, improved lipid profiles, and decreased blood pressure. Nutritional intervention studies establish guava as an effective food-based strategy for improving iron status in vulnerable populations through enhanced iron absorption, particularly in children and pregnant women. Additional clinical evidence supports guava's applications in musculoskeletal health (reducing knee pain), dermatological care (controlling sebum production), oral health (preventing gingivitis and reducing oral pathogens), and gastrointestinal disorders (alleviating diarrheal symptoms). These diverse therapeutic effects stem from guava's rich phytochemical profile, including flavonoids, carotenoids, and exceptionally high vitamin C content. The review highlights guava's versatility as a well-tolerated, accessible intervention that aligns with sustainable, food-based approaches to health management. While current evidence provides a foundation for guava's clinical applications, future research should further elucidate mechanisms of action, optimize preparations, and explore additional therapeutic potential. Guava emerges as a scientifically validated therapeutic agent with significant potential to improve health outcomes across diverse populations and conditions.
References
Lozoya X, Reyes-Morales H, Chávez-Soto MA, Martı́nez-Garcı́a M del C, Soto-González Y, Doubova S V. Intestinal anti-spasmodic effect of a phytodrug of Psidium guajava folia in the treatment of acute diarrheic disease. J Ethnopharmacol. 2002;83: 19–24. https://doi.org/10.1016/S0378-8741(02)00185-X
Singh RB, Rastogi SS, Singh R, Ghosh S, Niaz MA. Effects of guava intake on serum total and high-density lipoprotein cholesterol levels and on systemic blood pressure. Am J Cardiol. 1992;70: 1287–1291. https://doi.org/10.1016/0002-9149(92)90763-O
Roy Choudhury D, Nair Krishnapillai M, Nagalla B, Vijaya Kankipati R, Ghosh S, Buwade J, et al. Guava with an institutional supplementary meal improves iron status of preschoolers: a cluster‐randomized controlled trial. Ann N Y Acad Sci. 2021;1492: 82–95. https://doi.org/10.1111/nyas.14556
König A, Schwarzinger B, Stadlbauer V, Lanzerstorfer P, Iken M, Schwarzinger C, et al. Guava (Psidium guajava) Fruit Extract Prepared by Supercritical CO2 Extraction Inhibits Intestinal Glucose Resorption in a Double-Blind, Randomized Clinical Study. Nutrients. 2019;11: 1512. https://doi.org/10.3390/nu11071512
Tey SL, Lee DEM, Henry CJ. Fruit form influences postprandial glycemic response in elderly and young adults. J Nutr Health Aging. 2017;21: 887–891. https://doi.org/10.1007/s12603-017-0880-9
Thaptimthong T, Kasemsuk T, Sibmooh N, Unchern S. Platelet inhibitory effects of juices from Pachyrhizus erosus L. root and Psidium guajava L. fruit: a randomized controlled trial in healthy volunteers. BMC Complement Altern Med. 2016;16: 269. https://doi.org/10.1186/s12906-016-1255-1
Monárrez-Espino J, López-Alarcón M, Greiner T. Randomized Placebo-Controlled Trial of Guava Juice as a Source of Ascorbic Acid to Reduce Iron Deficiency in Tarahumara Indigenous Schoolchildren of Northern Mexico. J Am Coll Nutr. 2011;30: 191–200. https://doi.org/10.1080/07315724.2011.10719960
Wijaya-Erhardt M, Muslimatun S, Erhardt JG. Fermented soyabean and vitamin C-rich fruit: a possibility to circumvent the further decrease of iron status among iron-deficient pregnant women in Indonesia. Public Health Nutr. 2011;14: 2185–2196. https://doi.org/10.1017/S1368980011000954
Kakuo S, Fushimi T, Kawasaki K, Nakamura J, Ota N. Effects of Psidium guajava Linn. leaf extract in Japanese subjects with knee pain: a randomized, double-blind, placebo-controlled, parallel pilot study. Aging Clin Exp Res. 2018;30: 1391–1398. https://doi.org/10.1007/s40520-018-0953-6
Pongsakornpaisan P, Lourith N, Kanlayavattanakul M. Anti‐sebum efficacy of guava toner: A split‐face, randomized, single‐blind placebo‐controlled study. J Cosmet Dermatol. 2019;18: 1737–1741. https://doi.org/10.1111/jocd.12943
Wongsanao T, Leemingsawat W, Panapisal V, Kritpet T. Thermoregulatory effects of guava leaf extract-menthol toner application for post-exercise use. Pharm Biol. 2021;59: 852–857. https://doi.org/10.1080/13880209.2021.1942925
Amaliya A, Risdiana AS, Van der Velden U. Effect of guava and vitamin C supplementation on experimental gingivitis: A randomized clinical trial. J Clin Periodontol. 2018;45: 959–967. https://doi.org/10.1111/jcpe.12922
Singla S, Malhotra R, ND S, Saxena S. Antibacterial Efficacy of Mouthwash Prepared from Pomegranate, Grape Seed and Guava Extracts against Oral Streptococci: An in Vivo Study. Journal of Clinical Pediatric Dentistry. 2018;42: 109–113. https://doi.org/10.17796/1053-4628-42.2.5
Nayak N, Varghese J, Shetty S, Bhat V, Durgekar T, Lobo R, et al. Evaluation of a mouthrinse containing guava leaf extract as part of comprehensive oral care regimen- a randomized placebo-controlled clinical trial. BMC Complement Altern Med. 2019;19: 327. https://doi.org/10.1186/s12906-019-2745-8
Singh RB, Rastogi SS, Singh NK, Ghosh S, Gupta S, Niaz MA. Can guava fruit intake decrease blood pressure and blood lipids? J Hum Hypertens. 1993;7: 33–8. Available: http://www.ncbi.nlm.nih.gov/pubmed/8383769
Rani V, Moretti D, Khetarpaul N, Thankachan P, Zimmermann MB, Melse-Boonstra A, et al. Vitamin C-Rich Guava Consumed with Mungbean Dal Reduces Anemia and Increases Hemoglobin but not Iron Stores: A Randomized Controlled Trial of Food-to-Food Fortification in Indian Children. J Nutr. 2024;154: 3740–3748. https://doi.org/10.1016/j.tjnut.2024.10.042
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